4.1 Natural compounds Among various interventions targeting oxidative stress and muscle atrophy, natural compounds play a central role
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Improvements in body composition, deep sleep quality, and IGF-1 levels are documented in small trials, though long-term cancer risk monitoring of IGF-1 is necessary
These natural extracts are known for their anti-inflammatory properties, helping to minimize soreness and support faster recovery from strenuous workouts
A 2020 preclinical study evaluating gabapentin in an experimental colitis model demonstrated: Reduced visceral hypersensitivity Decreased inflammatory signaling Reduced mast cell density and activation markers in colonic tissue Downregulation of pro-inflammatory pathways (including NF-B signaling) Mast cells and enteric nerves communicate bidirectionally in the gut
Among the studies included in this systematic review, ten directly and one indirectly evaluated the effects of pharmacological interventions modulating this signaling pathway
