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Subsequent experiments indicated that control grafts showed features associated with exacerbated ferroptosis, including elevated LPO levels and suppression of the antioxidant system

Glutathione is a critical antioxidant found in almost every cell of the body

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303 Given the importance of ECM remodeling in CSC maintenance, therapeutic approaches targeting ECM-modifying enzymes such as matrix metalloproteinase inhibitors and lysyl oxidase inhibitors have been explored to impair CSC invasiveness and enhance treatment efficacy