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Citation17 ROS can activate the p38 MAPK pathway, which enhances p53 and p16 signaling, reinforcing senescence

MHRA-approved options in the UK include semaglutide (Wegovy) and tirzepatide (Mounjaro) for weight management, and orlistat for patients who cannot tolerate injectable therapies

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doi: 10.1542/PEDS.105.1.E15 [DOI] [PubMed] [Google Scholar] 5.Wardle J, Cooke L