Its inhibition at the tissue level without systemic suppression represents a pharmacologically favorable profile for research applications where inflammation is driving local tissue damage
More recently, a study showed that HSP90 is involved in the pathogenesis of pulmonary fibrosis 24 and more particularly in IPF 25,26
[13] After the final GSH product is made, it can be used by glutathione peroxidase to neutralize reactive oxygen species (ROS) such as H 2 O 2 or Glutathione S-transferases in the detoxification of xenobiotics
, :
3) could possibly lead to toxicity in the kidney, resulting in damage of the tubules, interstitium, glomerulus, or renal microvasculature, and consequently resulting in various clinical manifestations (Table 1) (Mayszko et al
Presents with right lower quadrant pain, diarrhea, and malabsorption