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At specified time intervals (0 h, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, 48 h), the sample solution (1.5 mL) was withdrawn from the dialysate, after which an equal volume of fresh corresponding solution (1.5 mL) was promptly added back into the dialysate to maintain the overall volume

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Documentation Elements: Pre-protocol baselines : Comprehensive initial measurements Daily administration logs : Timing, dosage, observations Weekly assessments : Structured evaluation periods Cycle completion analysis : Comprehensive outcome review Long-term tracking : Multi-cycle progression monitoring Research Protocol Variations by Objective Different research objectives may require modified epithalon dosage approaches