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Youre not alone many patients report unexpected musculoskeletal discomfort as their bodies rapidly shed pounds
Weight loss has been shown to improve symptoms in women with PCOS, but achieving and maintaining weight loss can be challenging
Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues
Peripherally in the gut, ghrelin was shown by us to stimulate gastric acid secretion and gastrin release (24) and to exhibit the gastro- and pancreato-protective activities against various irritants (25)
doi: 10.1016/j.biopsych.2013.04.022
After its removal, bile flows continuously from the liver directly into the small intestine rather than being stored and released in response to meals
