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Conversely, the addition of natural progesterone to estrogen resulted in a significant decrease in the estrogen-induced increase in breast cell proliferation rates

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Furthermore, we demonstrate that GLP-1R C347K and C347R mutant proteins can be activated by a non-specific five residue linker in the complete absence of GLP-1 or EX4 sequences, yet this activation remains completely dependent on the ECD, suggesting that the ECD plays a much more dominant and direct role in the receptor activation

As for the DUAL-1 study, the primary endpoint was to prove non-inferiority of the combination compared to glargine and superiority compared to lixisenatide

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