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The incidence and prevalence of kidney stones have consistently risen over the last half-century, and this trend is predicted to continue

Acetaldehyde is then oxidized by acetaldehyde dehydrogenases (ALDH2, ALDH1B1 and ALDH1A1) to acetate

Most (but not all) of the biological roles of Se, both as selenocysteine in selenoproteins, and as redox-active Se-containing metabolites, involve interactions with cysteine thiols and disulfides in proteins and peptides, and their various oxidized forms

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Statistical comparisons were conducted using the MannWhitney U-test in Prism version 8 (GraphPad Software, CA, USA)

10.1038/nbt.1503 2 Akhavan-TavakoliM.FardM.KhanjaniS.ZareS.EdalatkhahH.MehrabaniD.et al (2017)