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Anesthesia 74(6):778792

Reduced NO bioavailability and associated impairments in NOsGCcGMP signalling have been associated with CKD onset and progression in diabetes

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However, evidence suggests that minor, reversible epithelial microdamage does occur with the use of SNAC and whether chronic, repeat exposure and accumulation of such microdamage may overcome the natural self-healing capacity to restore the integrity of the barrier is naturally still a cause for concern