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Patients taking oral semaglutide (Rybelsus) should note that this medication must be taken on an empty stomach with a small amount of water, at least 30 minutes before the first food, beverage, or other oral medications of the day

For context, weekly semaglutide produced ~15% placebo-adjusted weight loss at 68 weeks in STEP 1, weekly tirzepatide produced ~21% at 72 weeks in SURMOUNT-1, and retatrutide hit 28.7% at 68 weeks in TRIUMPH-4

Prioritize high-protein foods, vegetables, and complex carbohydrates

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Clinical trials show that energy changes vary widelysome people feel noticeably more vital as excess weight lifts, while others initially experience fatigue during the body's metabolic adjustment phase