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A 2025 study in Neuroscience Letters found that chronic administration of BDNF-stimulating compounds in rodents led to receptor desensitization within 16 weeks, requiring progressively higher doses to maintain effect

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Jain PG, Patil SD, Haswani NG, Girase MV, Surana SJ

This twin discordance highlights the essential role of nongenetic factors, as shown in studies that only about 65% of identical twin pairs are concordant for the disease [5]

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Both peptides reduce pro-inflammatory cytokines, but through different pathways