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11, 29 Although it is unclear whether the accumulation of iron in the brain is primary or secondary to the development of neurodegenerative disorders, 30 one animal study has shown that unilateral injection of FeCl 3 into the substantia nigra of adult rats results in a 95% decrease of striatal dopamine, which impaired dopamine-related behavioral responses

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Akkermansia muciniphila This probiotic strain has garnered attention in clinical research due to its role in maintaining gut lining integrity and promoting metabolic balance

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Furthermore, intestinal I/R injury can activate the vagus nerve, transmitting signals to the brain that influence neuronal activity and cognitive function, and alter gut microbial metabolite production, such as short-chain fatty acids (SCFAs), thus affecting neuronal signaling and cognitive processes (Wu et al., 2021

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"Optimized tri-agonist design achieves superior metabolic outcomes in preclinical models." Molecular Metabolism

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Doxorubicin and ifosfamide are commonly used drugs, but response rates are often limited in sarcoma cases

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