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In cell culture assays addition of CART peptides results in phosphorylation of extracellular signal-regulated kinase (ERK) as well as the transcription factor, cyclic AMP response element binding protein (CREB)

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3.2 Dynamic Driving Network Identification Through sliding window GCA and cluster analysis, characteristic driving networks were identified for different headache stages: - VBM Recognized 5 Driving Clusters : - Clusters 1-2: Dominating low-frequency stage, involving sensorimotor and advanced association cortices - Cluster 3: Dominating transition to chronic stage, centered on limbic system and default network nodes - Clusters 4-5: Dominating chronic late stage, comprising subcortical structures and brainstem nuclei

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