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Vitamin D did not exhibit a ROS scavenger effect, and the antioxidant effect is presumably mediated via its receptor whose presence was confirmed in the varicose venous samples
doi: 10.4103/jhrs.JHRS_78_17 11 BarlampaDBompoulaMSBargiotaAKalantaridouSMastorakosGValsamakisG
[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Thomas H.N., Hamm M., Borrero S., Hess R., Thurston R.C
Antioxid Redox Signal 8(1112):20612073 Velusamy T, Panneerselvam AS, Purushottam M, Anusuyadevi M, Pal PK, Jain S et al (2017) Protective effect of antioxidants on neuronal dysfunction and plasticity in Huntingtons disease
A common cycling pattern is 4 weeks on, 4 weeks off to prevent tachyphylaxis, though continuous daily use has been studied in clinical trials for up to 14 days with good tolerability [2]