(European Journal of Endocrinology, 1998) confirmed that ipamorelin's ghrelin receptor agonism did not significantly elevate cortisol prolactin or ACTH in rat models compared to earlier GHRP classes
These can be the upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, altered NMDA receptor expression, altered dendritic morphology [167,168], and altered functioning of cholinergic (ACh-ergic) basal neurons, projecting to the cortex [169] by repeated exposure to amphetamine (amphetamine-induced sensitization)
10.1038/nrm2312 Nat
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Kihara, S., Wolle, J., Ehnholm, C., Chan, L