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TB-500 is a synthetic active fragment of thymosin beta-4, a naturally occurring intracellular protein

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Furthermore, free radicals could cause mitochondrial damages, followed by reduced energy production, and increased oxidative stress (6, 26)

Metformin treatment reduced insulin levels by 50%, and Atr and 4-DAMP did not alter the effect of metformin as shown by insulin AUC values ( Figures 2C, D )