Documented doses are animal-only: ~1.44-2.88 mg/kg oral in mice
Phase 1 data published 2021, Phase 2 data published 2023 (NEJM), the Phase 3 program TRIUMPH is ongoing: TRIUMPH-1 , Phase 3 obesity without T2D (n=2,100), results Q4 2025 TRIUMPH-2 , Phase 3 obesity + T2D (n=1,800), results 2026 TRIUMPH-3 , Phase 3 obesity + CV disease (n=1,900), results 2026 TRIUMPH-4 , Phase 3 obesity + knee osteoarthritis, results 2026 TRIUMPH-OUTCOMES , Phase 3 cardiovascular outcome trial (n=15,000+), results 2027 to 2028 FDA approval is expected at the earliest 2026 to 2027 in the obesity indication, similarly for T2DM
The 1998 RDAs for vitamin B6 for adults, in milligrams, are 1.3 mg for men and women ages 9-50 and 1.7 mg and 1.5 mg for men and women over the age of 51, respectively
Researchers contributing to this recent study predicted that the vast majority of ER visits would be driven by GI distress
Harris If nausea, bloating, or stomach discomfort becomes persistent and doesnt improve with smaller meals, hydration, or time
Endocrinology 140 , 34043410 (1999)
