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It was the hardest work upfront, but they did it and it paid dividends later

however, a substantial proportion of patients remain refractory and require alternative therapeutic approaches, including anti-IgE antibodies or other agents that inhibit mast cell activation and degranulation

However, the efficacy outcome (composite of cardiovascular mortality, MI, stroke, or stent thrombosis) was identical in the maximum tested dose of asundexian and placebo (5.5% each)

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