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Similarly, the concomitant downregulation of Adam19, a metalloproteinase closely associated with inflammation and oxidative stress-induced tissue remodeling 56 , further reinforces the hypothesis that APP treatment actively promotes endogenous antioxidant defenses and improves redox homeostasis rather than provoking nonspecific oxidative damage

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[PMC free article] [PubMed] [Google Scholar] 51.Zhu S, Layde PM, Guse CE, Laud PW, Pintar F, Nirula R, et al