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3 Although no studies have prospectively stratified patients by baseline A1C in evaluation of the A1C-lowering efficacy of a DPP-4 inhibitor or SGLT2 inhibitor, post-hoc subgroup analyses have shown that the efficacy of SGLT2 inhibitors is greater than that of DPP-4 inhibitors among patients with higher baseline A1C ( 8-8.5%), while patients with baseline A1C at the lower end of the spectrum ( 30 mL/min and clinical CV disease according to Diabetes Canada

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Renal Insufficiency DPP-4 inhibitors have also been examined in placebo-controlled studies in subjects with type 2 diabetes and chronic renal insufficiency, including patients with end-stage renal disease on dialysis (118121)

(2021) further assessed antioxidant and anticancer activities of phenolic-rich extracts from six medicinal plants, including E

As previously mentioned, GLP-1RAs inhibit the mTOR signaling pathway, which in turn alleviates the inhibitory effect on the cell cycle regulatory protein p27 [17]

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