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Nature 546 , 426430 (2017)

One major reason

Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

Glutathione supports the liver in the detoxification process from harmful substances such as heavy metals (lead, mercury), xenobiotics, toxic metabolites, and pesticides that can accumulate in cells

10.2 Nutritional deficiencies and skin manifestations in ketogenic interventions Nutritional deficiencies also negatively affect the appearance of the skin, often causing a number of severe skin conditions (240)

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