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Thyroid replacement (levothyroxine) absorption can be affected by GLP-1-induced slower gastric transit, so spacing doses 4+ hours apart from oral semaglutide or tirzepatide is recommended

Developing alternative ways to manage challenging emotions is key to long-term success

Patience required

Animal studies have demonstrated that overexpression of triggering receptor expressed on myeloid cells 2 (TREM2) in the hippocampus can improve cognitive dysfunction caused by long-term high-fat diets (HFD)

Another consideration is treatment fatigue

That might include coaching on nutrition, gentle activity, sleep, and stressall key pieces that help your body respond well to GLP-1 therapy