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Coffee (Black or Lightened) Black coffee contains virtually no calories

Reference: (1) P.Sikiric et al (2016) Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications Current Neuropharmacology, 2016;14(8):857-865

Gloss AD, Vasso DG, Hailey AL, Nelson Dittrich AC, Schramm K, Reichelt M

It signals to your brain that you've eaten enough, slows the rate at which food leaves your stomach, helps regulate blood sugar levels and supports healthy insulin release

In contrast, another meta-analysis by and (2015) [29] reports strong evidence of association between the genes glutathione-S-transferase (GST) and diabetic nephropathy (DN) polymorphisms

S., & Chandler, P