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Finally, and the most importantly, AANAT, the rate-limiting enzyme in the synthetic process of melatonin, resides in the mitochondria of pinealocytes and oocytes (Sakaguchi et al., 2013

2046) and nucleophosmin (NPM

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56 Further analysis revealed that artichoke leaf extract significantly improved quality of life in subjects with functional dyspepsia (ie, recurrent indigestion with no apparent cause)