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Hypoglycaemia risk: Retatrutide, like other incretin-class agents, stimulates insulin secretion in a glucose-dependent manner, meaning the risk of hypoglycaemia with monotherapy in otherwise healthy individuals is generally low

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Furthermore, in a Phase 1 randomized, double-blind, placebo-controlled clinical study (NCT04478708) in patients with obesity, adult obese subjects received either a single ascending dose (SAD) or multiple ascending doses (MAD) of AMG 133, compared with a placebo group