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What few studies have been done in the pancreas (Koehler et al , 2009), while they did show some downregulation of specific cytokines (By itself, downregulation of specific cytokines is a rather unremarkable effect on the immune system, plenty of substances, that dont cure anything, can have similar effects), it did not show any actual improvements in outcomes in a rodent model of pancreatic inflammation

De Luca F, Shoenfeld Y

Understanding which situation applies requires looking at both clinical response over time and the genetic variants that shape the relevant pathways