Consistent with attenuating the destructive effects of oxidative stress, presented evidence showed that Moringa oleifera extracts could effectively reduce the elevated levels of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-), IL-1, IL-6, cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), and chemokine (MCP-1) to protect against exacerbated inflammation, under sustained conditions of hyperglycemia (Muhammad et al., 2016
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In the early stages of diabetes, kidney hemodynamic changes, inflammation, and fibrosis occur due to metabolic alterations such as hyperglycemia, systemic hypertension, hyperaminoacidemia, and obesity
