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Studies indicate a physiological role for umami (TAS1R1/R3) and bitter TRs, yet, the relevance of the sweet TR T1R2/T1R3 is highly controversial (15, 19, 27)

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Plant Physiol 128:14551469 Biancucci M et al (2015) Role of proline and GABA in sexual reproduction of angiosperms

It also reduces satiety between meals

Crucially, Crat knockout experiments partially reversed these metabolic improvements, establishing CrAT-mediated SREBP1c inhibition as a key mechanism through which L-carnitine counteracts de novo lipogenesis