In another investigation by Fahmy et al., B12 serum levels were positively correlated with language, visuospatial, and global cognitive scores but negatively correlated with attention ability in patients with MS [125]
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NICE Clinical Knowledge Summaries recommend B12 injections for: Pernicious anaemia an autoimmune condition affecting intrinsic factor production Malabsorption syndromes including coeliac disease and inflammatory bowel disease Post-surgical states particularly following gastrectomy or ileal resection Strict vegan diets when oral supplementation proves inadequate, though oral cyanocobalamin is usually sufficient for dietary deficiency Clinical trials demonstrate that B12 injections rapidly improve haematological parameters and neurological symptoms when deficiency is confirmed through blood tests
Neuroblastoma: an evaluation of its natural history and the effects of therapy, with particular reference to treatment by massive doses of vitamin B12
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As AOD-9604 does not interact with the growth hormone receptor, it was not shown to stimulate IGF-1 production and showed no proliferative effects on growth-related endpoints (Fawcett 2010)
