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Ainda no existem ensaios clnicos randomizados de larga escala em humanos

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A different approach with higher construct validity is using well-known disease-causing mutations to generate animal models [216]

If lipolytic response diminishes after 16+ weeks, a 4-week washout restores baseline sensitivity

found that MDA and 4-HNE levels were increased in the synovial cells of OA patients compared to healthy controls, and 4-HNE levels were also increased in synovial fluid of OA patients

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