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While various antidiabetic medications are available, individuals with type 1 diabetes rely on lifelong insulin therapy, and those with type 2 diabetes may also require it if other oral treatments prove ineffective

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It has been shown that activation of HSCs can exacerbate the degree of hepatic fibrosis (272)

However, genetic factorsincluding variants in GLP1R, GIPR, and FTO pathwaysmay influence how effectively different GLP-1 formulations work for each person, potentially affecting long-term cost-effectiveness and treatment outcomes

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