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We also confirmed these results in a parallel experiment by determining a 2.6 cryo-EM reconstruction of PV3-SC8 bound to GSH and an alternative VP1 hydrophobic pocket binding drug, pleconaril (Supplementary Figs

The absorbance was measured at 375 nm on a UVVIS Spectrophotometer Pharo 300 Spectroquant (Merck, Darmstadt, Germany)

This leads to elevated IGF-1, promoting anabolic and lipolytic activity primarily in adipose tissue, particularly reducing VAT with minimal impact on subcutaneous fat