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& Moyle, P

It has been found to be effective in achieving clinically significant weight loss, with about four patients needing to be treated with naltrexone/bupropion instead of placebo for one additional patient to achieve at least a 5% weight loss

Horm Metab Res (2021) 53(6):4027

Why Your Body Resists Permanent Weight Loss After Stopping Treatment Your body has built-in mechanisms to defend against sustained weight loss, a phenomenon called adaptive thermogenesis

It acts as a sling to support crucial organs like the bladder, bowels, and uterus

The table shows that SGLT2is and aldosterone antagonists provide the most robust and additive reductions in albuminuria and CKD progression, with SGLT2is showing consistent benefit across all albuminuria and eGFR levels [122]