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doi: 10.3390/nu11102524 162 SepidarkishMMorvaridzadehMAkbari-FakhrabadiMAlmasi-HashianiARezaeinejadMHeshmatiJ

LPS-induced cardiac dysfunction recovered in DPP-4 deficient rats after treatment with sitagliptin

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In summary, our study uncovered a novel role of adipocyte-expressed SIRT3 in mitigating infiltration and pro-inflammatory polarization of macrophages, thereby attenuating AT inflammation and protecting against obesity-related insulin resistance

Or maybe targeted therapy to destroy cells with certain genetic changes (mutations)