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Recommended starting dose: 500 mg (0.5 grams) once daily, mixed in a full glass of water

Tirzepatide has shown a slightly higher rate of acute gallbladder disease (0.6% versus essentially zero in placebo groups), which can secondarily affect liver function through biliary obstruction

Suryadevara V, Roy A, Sahoo J, Kamalanathan S, Naik D, Mohan P, et al

While also not prescribing GLP-1s personally, Brandon Peters, MD, FAASM, a sleep physician at Virginia Mason Medical Center, has patients taking GLP-1s for obesity or diabetes and seeing improvements in their OSA

Risk of bias using Cochrane risk-of-bias tool for randomized trials-Kosibord, 2023