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Society guidelines have left clinicians with some questionable recommendations Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs), such as semaglutide and tirzepatide, are becoming increasingly prescribed to treat diabetes mellitus and obesity

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If the fissure has not responded to topical GTN over eight weeks then the patient should be referred to a specialist, who may consider surgery to reduce anal sphincter tone

A deficiency of any one impairs blood cell formation and can lead to the formation of abnormal blood cells that cant effectively carry oxygen

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