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Possible side effects include mild digestive changes (gas, bloating, or altered bowel habits) as your gut adjusts to the polyphenol content

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Kawada, T., Hagihara, K

The most common reasons are reducing GI side effects during titration and stretching supply when access is limited

[43] Assay [edit] Several in vitro biochemical assays have been applied to monitor the catalytic activity of gamma-butyrobetaine dioxygenase