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Cureus, 16(3), e55771

Self-administration of either compound without medical supervision represents a significant and unquantified health risk

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This problem is compounded by the intrinsically dynamic character of the 7TM bundle 14, 15 and the relative instability of GPCR complexes, such as with G proteins 16 or arrestins 17 , often resulting in conformational variability or even dissociation during cryo-EM specimen preparation