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One of the roles of GLP-1 is to signal the body to produce more insulin, reducing blood glucose (sugar)
Protection of hippocampal neurons from ischemia-induced delayed death by hepatocyte growth factor: a novel neurotrophic factor
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The figure below summarizes that, to date, the structures of eight different small molecule agonists have been resolved, all of which are located near the extracellular ligand-binding pocket compared to the GLP-1 peptide
28 , 38573863.e3 (2018)
The most common adverse events are gastrointestinal: nausea (occurring in 12-33% of subjects depending on dose), diarrhea, constipation, and decreased appetite
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