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Phase Cag introduction Weeks 9-12 Tirzepatide 5.0 mg/week (hold) Cagrilintide 0.25 mg/week Notes Add cagrilintide at the lowest dose

The nasal administration method simplifies accessibility and ensures efficient delivery during experimental procedures

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Elevated numbers of Th17 cells and increased levels of Th17-related cytokines, including IL-17 and IL-22, have been reported in HT, correlating with disease severity and autoantibody titers

The PRL receptor is not overexpressed in human prostate cancers (180)

Instead, it specifically targets adipose tissue metabolism through alternative pathways