Constantin IM, Voruz P, Pron JA
Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition
However, markers of apoptosis and DNA fragmentation were not significantly changed
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This is thought to occur through modulation of key signaling pathways like NF-B
Increased energy enables intensive and extended workouts, promoting the fat burning process for that cut-up, hard body look