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doi: 10.2353/ajpath.2010.090457

The same 2mL added to a 10mg vial gives you 5mg/mL, double the concentration

The Pernicious Anaemia Society notes this is well documented but poorly understood, and that some patients self-inject more frequently

There are different forms of B12 used in injections

In more rare yet severe cases, you may experience: Itching or a feeling of swelling all over the body Muscle cramps and weakness Upset stomach and urinary problems Swelling in the ankles or feet Unusual tiredness Irregular heartbeat or trouble breathing If these side effects occur, consult your healthcare provider before continuing B12/MIC

The mechanism is proposed to involve G-protein coupled receptor signaling, but definitive identification of the functional receptor has not been published