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4 Conclusion In general, the auto-reactive cellular immune responses including osteoclasts, synovial fibroblasts, T cells, B cells, NK cells, macrophages and DCs, play major roles in RA pathogenesis, although soluble inflammatory and rheumatoid factors with inflammatory natures were also involved

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Complementary Anti-Inflammatory Profiles: Their combined action may reduce systemic inflammation while promoting regenerative cytokines, creating a favorable environment for healing

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