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More women reached clinically meaningful weight-loss thresholds, and cardiometabolic markers improved to a greater degree

However, their application in GLP-1RA is restricted by challenges such as the poor skin permeability of macromolecular drugs and the need for advanced formulation techniques [15,16]

Zafarullah M, Li WQ, Sylvester J, Ahmad M

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Retatrutide induces greater body weight losses in obese mice than tirzepatide, due to an increased energy expenditure through GCGR activation 6

Combining meaningful weight loss with proven cardiovascular benefits in an oral formulation could be a game changer for both patients and healthcare providers