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In cryopreservation systems containing permeable cryoprotectants, antioxidants may exert enhanced efficacy by facilitating intracellular penetration and direct scavenging of ROS, whereas in non-permeable cryoprotectant systems, their action predominantly relies on extracellular radical neutralization (91, 92)

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FDA-Approved Uses Notably, both medications have approved uses that are quite similar, with some key distinctions related to heart failure that are bolded below

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Critical Clarification: Research Context The clinical trial results cited above are from studies on FDA-approved brand-name medications manufactured by major pharmaceutical companies