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To confirm that increases in islet GLP-1 expression correspond with increases in the active form of GLP-1, we measured active GLP-1 in islet protein lysates from islets from a human donor (Supplemental Figure 5B) following 24 hours of treatment with saline or liraglutide

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ABSTRACT Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated considerable efficacy in the treatment of diabetes and obesity, it is essential to recognize that their use is associated with certain intrinsic risks that must not be disregarded

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