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Kidney-targeted delivery systemssuch as PEGylated lipid nanoparticles (LNPs) modified with renal tubular cell-targeting ligands (e.g., vitamin B12, which binds to cubilin on PT cells)have shown promise in preclinical studies, increasing renal Fer-1 accumulation by 510-fold and reducing systemic toxicity

DOI: 10.1080/03007995.2017.1292230

Anabolic Signaling IGF-1 LR3 activates the same cellular pathways as natural IGF-1 , stimulating protein synthesis, promoting cellular proliferation, and enhancing nutrient uptake in muscle and other tissues

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doi: 10.1016/j.abb.2020.108546 192