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doi:10.1111/tpj.16961

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This effect of GLP-1(2836) was independent of the known GLP-1R and was mediated by a mechanism involving mitochondrial MTP and intracellular sAC in caSMCs and caECs but not CMs

One phase IIb clinical trial administered setmelanotide to obese participants with heterozygous MC4R deficiency and obese controls over 28 days, observing a placebo-adjusted weight loss of 2.6 kg and 4.0 kg respectively [98]

Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG, et al

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