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doi: 10.1016/j.appet.2008.12.003, 49 GearhardtA

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents

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The relevance to humans is unclear, but these medications are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Except for dihexa, all drug solutions were prepared in HPLC-grade water at 5 mg/ml