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they reshape our understanding of obesity as a chronic disease that requires long-term management
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These include: Increased appetite and food cravings , which may work against Wegovy's appetite-suppressing effects Insulin resistance and elevated blood glucose levels , potentially leading to steroid-induced diabetes Fluid retention and weight gain , particularly in the face, neck, and trunk (cushingoid features) Redistribution of body fat to central areas Muscle wasting , which can reduce metabolic rate Patients taking both medications may experience reduced weight loss efficacy compared to those taking Wegovy alone, though the appetite-suppressing effects of Wegovy may help mitigate steroid-induced hunger
Sodeifian, G., Nasri, L., Razmimanesh, F
doi: 10.1210/jc.2003-031403 71 MartinsFLBaileyMAGirardiACC
